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The effect of ketoprophen on lumbar spinal fusion healing in a rabbit model. Laboratory investigation.

J Neurosurg Spine. 2007 Dec;7(6):631-6

Authors: Urrutia J, Mardones R, Quezada F

OBJECT: Several reports have shown that nonsteroidal antiinflammatory drugs (NSAIDs) have an inhibitory effect in osteogenesis and reduce heterotopic ossification in humans. A deleterious effect of NSAIDs in posterolateral intertransverse process fusion has also been suggested. The authors used a validated rabbit model to try to determine the influence of the NSAID ketoprophen on the fusion rate in lumbar spinal arthrodesis. METHODS: Thirty New Zealand male rabbits underwent posterolateral (intertransverse process) bilateral spinal fusions at a single level, using autologous bone graft obtained from both iliac crests. The animals were randomized after the operation, so that 15 rabbits received ketoprophen as a postoperative analgesic and the other 15 received the postoperative analgesic tramadol. The animals were killed 8 weeks after surgery, and fusion status was determined by inspection, palpation, anteroposterior radiographs, and histological analysis. RESULTS: A solid fusion was obtained in eight rabbits (53%), and pseudarthrosis in seven rabbits (47%) in each group. CONCLUSIONS: These findings suggest that the use of ketoprophen after intertransverse spinal fusion at a single level does not decrease the fusion rate, compared with tramadol.

PMID: 18074688 [PubMed - indexed for MEDLINE]

(Source: Journal of Neurosurgery.Spine)

Valeant Pharmaceuticals International (NYSE:VRX) announced that it has enrolled the first patient in its Phase 2 clinical trial of retigabine for the treatment of pain associated with postherpetic neuralgia (PHN), a painful and common complication of shingles. "We are eager to investigate whether retigabine, our new novel potassium channel opener, will be effective in treating neuropathic pain," said Timothy C. Tyson, president and chief executive officer. [click link for full article]

Not every breakthrough is positive. Of the approximately 1.4 million new cancer patients in the U.S. each year, more than half experience pain associated with their disease. The patient's level of pain changes throughout the day, with many patients experiencing two kinds of chronic cancer pain: persistent pain and what is known as "breakthrough pain" (BTP). [click link for full article]

Two fibro-cartilaginous crescents, the menisci serve as cushions against joint cartilage degradation where the knee connects with the shin and thigh bones. Loss of meniscal function is recognized as a strong risk factor for knee osteoarthritis (OA). In the United States, about 6 percent of the over 30 through middle-age population and between 11 and 15 percent of senior citizens, age 65 and up, suffer from knee OA in form of frequent knee pain, aching, or stiffness. [click link for full article]

An estimated nine million men and women in the United States live with myofascial pain syndrome, a condition marked by pain that permeates muscles in the neck, back and shoulders. The condition is difficult to diagnose and not entirely understood, but research studies indicate that a new imaging technology developed at Mayo Clinic holds promise for a definitive diagnosis and, perhaps eventually, new treatments for people who have the syndrome. [click link for full article]

Known scientists argue that better Ultram or Tramadol

Known scientists argue that better Ultram or Tramadol

Radiologists are using a new minimally invasive procedure to treat tendonitis in the shoulder. Ultrasound-guided non-surgical therapy significantly reduces pain from calcific tendonitis of the rotator cuff and restores mobility, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA). "This is a quick, successful and inexpensive therapy for tendon calcifications," said Luca M. Sconfienza, M.D. [click link for full article]

Statins, the popular class of drugs used to lower cholesterol, are among the most commonly prescribed medications in developed countries. But for some patients, accompanying side effects of muscle weakness and pain become chronic problems and, in rare cases, can escalate to debilitating and even life-threatening damage.Now a study led by investigators at Beth Israel Deaconess Medical Center (BIDMC), helps explain the source of these problems. [click link for full article]

Cryoablation, a procedure most commonly associated with destroying kidney and prostate tumors by freezing them, has been shown to offer durable pain relief of cancer that has spread to bone. The procedure freezes and shrinks or destroys cancerous tumors in or near bone."Cancer patients are living longer and we need to be able to manage their pain over a long period of time," says Matthew Callstrom, M.D., Ph.D. [click link for full article]